Background and overview[1-2]
Dodecaethylene glycol monomethyl ether, also known as dodecaethylene glycol monomethyl ether, is a kind of oligoethylene glycol monomethyl ether. Alcohol derivatives. There are literature reports that dodecaethylene glycol monomethyl ether can be used to prepare polyol monomethyl ether trimethylsilane or ribavirin derivatives.
Application[1-2]
Application 1.
Dodecaethylene glycol monomethyl ether can be used to prepare polyols Monomethyl ether trimethylsilane. Polyol monomethyl ether trimethylsilane can be used as a lithium battery electrolyte additive. The preparation steps are as follows:
① Put compound I into the reaction kettle, and then add cation exchange resin as a catalyst into the reaction kettle;
② Add compound II dropwise into the reaction kettle, As the reaction proceeds, ammonia will be produced as a by-product, and the dripping temperature is controlled at 10°C to 100°C;
③ After the dripping is completed, the reaction kettle is kept warm at a temperature of 10°C to 120°C reaction;
④ After the insulation reaction is completed, the temperature is lowered, and then the catalyst in the reaction solution is filtered out;
⑤ After the reaction solution is distilled under reduced pressure, polyol monomethyl ether trimethyl is obtained Silane.
Compound Ⅰ is hexamethyldisilazane; compound Ⅱ is selected from ethylene glycol monomethyl ether, diethylene glycol monomethyl ether, triethylene glycol monomethyl ether, and tetraethylene glycol monomethyl ether. Methyl ether, hexaethylene glycol monomethyl ether, octaethylene glycol monomethyl ether, decaethylene glycol monomethyl ether, dodecaethylene glycol monomethyl ether, propylene glycol monomethyl ether, dipropylene glycol monomethyl ether, triisopropylene glycol One of the monomethyl ethers.
Application 2.
Dodecaethylene glycol monomethyl ether can be used to prepare the following ribavirin derivative. The ribavirin derivative can overcome the problems of hemolytic side effects and long residual time in the human body existing in the existing technology.
References
[1] [China invention, China invention authorization] CN201510323131.8 Polyol mono Preparation method of methyl ether trimethylsilane
[2] [Chinese invention] CN201811565840.7 Ribavirin derivative preparation and preparation method thereof
